The present invention provides a pre-coding method in a multi-user macro-diversity transmission system. The method comprises: obtaining, for a mobile station in the multi-user macro-diversity transmission system, a first sub-precoder that guarantees orthogonality between equivalent channels of users; obtaining a second sub-precoder by performing QR decomposition based on equivalent channels precoded through the first sub-precoder; obtaining a final pre-coder with respect to the mobile station by combining the first sub-precoder and the second sub-precoder; and performing pre-coding on data of the mobile station with the final precoder The present invention further provides a corresponding base station and a multi-user macro-diversity transmission system. Through the technical solution of the present invention, the multi-user macro-diversity transmission system may achieve more macro-diversity gain, thereby greatly enhancing the performance of the multi-user macro-diversity transmission.