A system and method are provided for determining a time for safely sampling a signal of a clock domain. In one embodiment, a phase estimate of a first clock domain is calculated based on a relative frequency estimate between a second clock domain and the first clock domain and, based on the phase estimate, a first time during which a signal from the first clock domain is unchanging such that the signal is capable of being safely sampled by the second clock domain is determined to generate a first sampled signal in the second clock domain. Additionally, an updated phase estimate is calculated, and, based on the updated phase estimate, a second time during which the signal from the first clock domain is changing such that the signal is not capable of being safely sampled by the second clock domain is determined. During the second time the first sampled signal in the second clock domain is maintained.