A method and system for access and uplink power control for a wireless system having multiple transmit points. In one aspect, a method at a user equipment operating in a wireless network having a plurality of transmission points including a macro evolved Node B (‘eNB’) and at least one low power node (‘LPN’) having transmit power lower than that of the macro eNB, the method finding, at the user equipment, at least one reference transmission point, the finding utilizing at least one of a calculation at the user equipment and a message from a network element; and performing, by the user equipment, uplink power control based on the at least one reference transmission.