An out of front knife with an assisted opening mechanism has a handle, a blade mounted in the handle, a thumb stud that drives the blade, and an extending assembly that assists with extending the blade out of the handle. With two sliders and two springs of the extending assembly, only when the blade is intentionally pushed to move a preset distance and overcome a preset resistance, one of the springs pulls and assists the blade of the out of front knife to extend out of the handle. Therefore, the out of front knife with the assisted opening mechanism is used safely.