An anthropomorphic phantom for medical imaging systems is disclosed, which is configured with organ models designed to mimic the three-dimensional shape of human organs, and also by the arrangement of plate-like first connecting elements inside their corresponding organ models, lesion phantoms for simulating tumors can be fixedly secured inside the corresponding organ model using a plurality of first connection holes formed on the first connecting element. Therefore, by the distribution of those first connection holes, not only the lesion phantoms can be arranged at any position inside the corresponding organ model at will as required, but also by modularized design of the anthropomorphic phantom, organ models can first be assembled to form a module structure while the whole module structure with the organ model can be moved into and assembled easily with a torso-like humanoid housing of the anthropomorphic phantom by the use of a handle element.