A lice, flea or other parasitic insect comb has a handle that extends over top of the metal teeth of the comb and is shaped to be comfortable in the hand. The handle can comprise a U-shaped portion having a hand grip portion and a pair of spaced-apart struts that extend between the hand grip portion and the metal teeth of the comb. Preferably, the hand grip portion is spaced from a plane containing or aligned with the metal teeth and is vertically aligned with the metal teeth of the comb. Such a handle configuration can facilitate positioning of the teeth of the comb substantially flat against or parallel to the scalp, which makes removal of lice and nits more effective. In some configurations, the comb teeth can be wider than standard lice combs, so it covers more hair and therefore takes less time to remove nits and lice.