What is disclosed is a system and method for printing a cancellation mark on a ticket using inks having thermo-reactive properties. One embodiment of the present method for printing a cancellation mark onto a ticket involves the following. A ticket, which has a security mark printed thereon, is received into a slot of a housing of a device which contains therein an inkjet printhead. The received ticket portion comes into proximity with an inkjet printhead configured to print a cancellation mark on the ticket using the thermo-reactive ink. The cancellation mark is printed to at least partially overlap the security mark. In one embodiment, a user activates a switch which causes the inkjet printhead to print the cancellation mark on the ticket upon the ticket having been inserted into the slot. Various embodiments are disclosed.