An illuminated surgical instrument is disclosed. One embodiment of the present invention comprises an illuminated vitrectomy probe. The vitrectomy probe has a cutting port disposed at a distal end of a cannula. An array of optical fibers terminates near the cutting port. The array of optical fibers is located adjacent to the cannula and encircling the cannula. The array of optical fibers can comprise two sets of fibers, one for providing illumination in a direction along a longitudinal axis of the vitrectomy probe and another for providing illumination in a direction at an angle to the longitudinal direction of the vitrectomy probe. The light source providing light to each set of fibers can be independently controlled so as to provide illumination cooperatively or singly.