Invention Grant
- Patent Title: Method of inhibiting vascular intimal hyperplasia using stent
- Patent Title (中): 使用支架抑制血管内膜增生的方法
-
Application No.: US13561828Application Date: 2012-07-30
-
Publication No.: US08968392B2Publication Date: 2015-03-03
- Inventor: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- Applicant: Ikuo Omura , Zhen Yu Jin , Shuzo Yamashita , Hiroo Iwata , Akira Mochizuki
- Applicant Address: JP Okayama JP Tokyo JP Hiroshima JP Kyoto
- Assignee: Japan Stent Technology Co., Ltd.,Tokai University Educational System,Toyo Advanced Technologies Co., Ltd.,Hiroo Iwata
- Current Assignee: Japan Stent Technology Co., Ltd.,Tokai University Educational System,Toyo Advanced Technologies Co., Ltd.,Hiroo Iwata
- Current Assignee Address: JP Okayama JP Tokyo JP Hiroshima JP Kyoto
- Priority: JP2007-228788 20070904
- Main IPC: A61F2/82
- IPC: A61F2/82 ; A61F2/00 ; A61L33/00 ; A61F2/915 ; A61K9/00 ; A61L31/10 ; A61L31/16 ; A61F2/91

Abstract:
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
Public/Granted literature
- US20130018455A1 METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT Public/Granted day:2013-01-17
Information query
IPC分类: