Invention Grant
US08968719B2 Live, oral vaccine for protection against Shigella dysenteriae serotype 1
有权
用于保护痢疾志贺氏菌血清型1的活的口服疫苗
- Patent Title: Live, oral vaccine for protection against Shigella dysenteriae serotype 1
- Patent Title (中): 用于保护痢疾志贺氏菌血清型1的活的口服疫苗
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Application No.: US14145104Application Date: 2013-12-31
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Publication No.: US08968719B2Publication Date: 2015-03-03
- Inventor: Dennis J. Kopecko , De-Qi Xu
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Rockville
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Sevices
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Sevices
- Current Assignee Address: US MD Rockville
- Agency: Swanson & Bratschun, L.L.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K39/02 ; A61K39/116 ; A61K39/112 ; C07K14/25 ; C12N15/52 ; A61K39/00
Abstract:
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
Public/Granted literature
- US20140120134A1 LIVE, ORAL VACCINE FOR PROTECTION AGAINST SHIGELLA DYSENTERIAE SEROTYPE 1 Public/Granted day:2014-05-01
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