Invention Grant
- Patent Title: FcγRIIB specific antibodies and methods of use thereof
- Patent Title (中): FcγRIIB特异性抗体及其使用方法
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Application No.: US12167765Application Date: 2008-07-03
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Publication No.: US08968730B2Publication Date: 2015-03-03
- Inventor: Scott Koenig , Maria Concetta Veri , Nadine Tuaillon
- Applicant: Scott Koenig , Maria Concetta Veri , Nadine Tuaillon
- Applicant Address: US MD Rockville
- Assignee: MacroGenics Inc.
- Current Assignee: MacroGenics Inc.
- Current Assignee Address: US MD Rockville
- Agency: AuerbachSchrot LLC
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/40 ; C07K16/28 ; C07K16/00 ; A61K39/00
Abstract:
The present invention relates to antibodies or fragments thereof that specifically bind the extracellular domain of FcγRIIB, particularly human FcγRIIB, and block the Fc binding site of human FcγRIIB. The invention provides methods of treating cancer and/or regulating immune complex-mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.
Public/Granted literature
- US20090092610A1 FcGammaRIIB Specific Antibodies and Methods of Use Thereof Public/Granted day:2009-04-09
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