Invention Grant
- Patent Title: Protease assay
- Patent Title (中): 蛋白酶测定
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Application No.: US12920771Application Date: 2009-03-03
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Publication No.: US08969027B2Publication Date: 2015-03-03
- Inventor: Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel
- Applicant: Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel
- Applicant Address: US KS Manhattan
- Assignee: Kansas State University Research Foundation
- Current Assignee: Kansas State University Research Foundation
- Current Assignee Address: US KS Manhattan
- Agency: Hovey Williams LLP
- International Application: PCT/US2009/035875 WO 20090303
- International Announcement: WO2009/111470 WO 20090911
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; C12N11/06 ; A61K49/14 ; C12N11/00 ; C12N11/14 ; A61K49/00 ; B82Y15/00 ; C07K5/113 ; C07K7/06 ; C07K7/08 ; G01N33/58 ; C12N11/02 ; C12N11/04
Abstract:
The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
Public/Granted literature
- US20110014125A1 PROTEASE ASSAY Public/Granted day:2011-01-20
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