Invention Grant
US08969061B2 Compositions, methods and related uses for cleaving modified DNA
有权
用于切割修饰的DNA的组合物，方法和相关用途
- Patent Title: Compositions, methods and related uses for cleaving modified DNA
- Patent Title (中): 用于切割修饰的DNA的组合物，方法和相关用途
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Application No.: US13522224Application Date: 2011-01-20
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Publication No.: US08969061B2Publication Date: 2015-03-03
- Inventor: Zhenyu Zhu , Yu Zheng , Shengxi Guan , Hua Wang , Aine Quimby , Penghua Zhang , Lynne Apone
- Applicant: Zhenyu Zhu , Yu Zheng , Shengxi Guan , Hua Wang , Aine Quimby , Penghua Zhang , Lynne Apone
- Applicant Address: US MA Ipswich
- Assignee: New England Biolabs, Inc.
- Current Assignee: New England Biolabs, Inc.
- Current Assignee Address: US MA Ipswich
- Agency: New England Biolabs, Inc
- Agent Harriet M. Strimpel
- International Application: PCT/US2011/021879 WO 20110120
- International Announcement: WO2011/091146 WO 20110728
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/68 ; C12Q1/34 ; C12N9/00 ; C12N9/22
Abstract:
Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3′ of the recognition site to produce a cleavage fragment with a 1-3 base overhang.
Public/Granted literature
- US20120301881A1 Compositions, Methods and Related Uses for Cleaving Modified DNA Public/Granted day:2012-11-29
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