Invention Grant
- Patent Title: Enhanced pyruvate to acetolactate conversion in yeast
- Patent Title (中): 增强酵母中的丙酮酸至乙酰乳酸转化
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Application No.: US14161619Application Date: 2014-01-22
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Publication No.: US08969065B2Publication Date: 2015-03-03
- Inventor: Larry Cameron Anthony , Lori Ann Maggio-Hall
- Applicant: Butamax Advanced Biofuels LLC
- Applicant Address: US DE
- Assignee: Butamax Advanced Biofuels LLC
- Current Assignee: Butamax Advanced Biofuels LLC
- Current Assignee Address: US DE
- Main IPC: C12N1/16
- IPC: C12N1/16 ; C12P7/16 ; C12N9/88 ; C12P7/04
Abstract:
A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains.
Public/Granted literature
- US20140162333A1 Enhanced Pyruvate to Acetolactate Conversion in Yeast Public/Granted day:2014-06-12
Information query
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