Invention Grant
US08969100B2 Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells
有权
检测传入淋巴管流入区域的方法和识别特定细胞的方法
- Patent Title: Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells
- Patent Title (中): 检测传入淋巴管流入区域的方法和识别特定细胞的方法
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Application No.: US13379320Application Date: 2010-03-11
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Publication No.: US08969100B2Publication Date: 2015-03-03
- Inventor: Makoto Hikage , Kohsuke Gonda , Motohiro Takeda , Takashi Kamei , Noriaki Ohuchi , Hideki Gouda , Yasushi Nakano
- Applicant: Makoto Hikage , Kohsuke Gonda , Motohiro Takeda , Takashi Kamei , Noriaki Ohuchi , Hideki Gouda , Yasushi Nakano
- Applicant Address: JP Miyagi JP Tokyo
- Assignee: Tohoku University,Konica Minolta Medical & Graphic, Inc.
- Current Assignee: Tohoku University,Konica Minolta Medical & Graphic, Inc.
- Current Assignee Address: JP Miyagi JP Tokyo
- Agency: Lucas & Mercanti, LLP
- Priority: JP2009-152781 20090626
- International Application: PCT/JP2010/054083 WO 20100311
- International Announcement: WO2010/150578 WO 20101229
- Main IPC: G01N33/543
- IPC: G01N33/543 ; G01N33/574 ; G01N21/64 ; A61K49/00 ; B82Y5/00 ; B82Y15/00 ; G01N33/58 ; A61B5/00

Abstract:
Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby identifying the location of the sentinel lymph node by means of fluorescence. Subsequently, the sentinel lymph node is extracted. With respect to the sentinel lymph node extracted with quantum dots injected, structural analysis is conducted by means of precision fluorescence measurement which uses a confocal fluorescence microscope for monomolecular observation. Specifically, the fluorescence intensity is measured with respect to each of multiple areas in the sentinel lymph nodes, and out of the multiple areas measured, one or more areas are detected as afferent lymph vessel inflow regions in descending order of fluorescence intensity.
Public/Granted literature
- US20120107831A1 METHOD FOR DETECTING AFFERENT LYMPH VESSEL INFLOW REGIONS AND METHOD FOR IDENTIFYING SPECIFIC CELLS Public/Granted day:2012-05-03
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