Invention Grant
- Patent Title: TGFP-CAP peptide and its uses
- Patent Title (中): TGFP-CAP肽及其用途
-
Application No.: US12596479Application Date: 2007-09-12
-
Publication No.: US08969296B2Publication Date: 2015-03-03
- Inventor: Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
- Applicant: Yong-Ji Chung , Young Deug Kim , Eun Mi Kim , Jun Young Choi , Jin Seuk Kim , Sang Su Song , Kyoung Mi Cho
- Applicant Address: KR Gunpo-si, Gyeonggi-do
- Assignee: Caregen Co., Ltd
- Current Assignee: Caregen Co., Ltd
- Current Assignee Address: KR Gunpo-si, Gyeonggi-do
- Agency: Clark & Elbing LLP
- Priority: KR10-2007-0038531 20070419
- International Application: PCT/KR2007/004405 WO 20070912
- International Announcement: WO2008/130082 WO 20081030
- Main IPC: A61K8/64
- IPC: A61K8/64 ; C07K7/08 ; A61K38/00 ; C07K14/495 ; A61K38/18 ; A61Q19/02
Abstract:
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
Public/Granted literature
- US20100160238A1 TGFP-CAP Peptide and its Uses Public/Granted day:2010-06-24
Information query
