Invention Grant
- Patent Title: Diamino heterocyclic carboxamide compound
- Patent Title (中): 二氨基杂环羧酰胺化合物
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Application No.: US13266164Application Date: 2010-05-06
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Publication No.: US08969336B2Publication Date: 2015-03-03
- Inventor: Itsuro Shimada , Kazuo Kurosawa , Takahiro Matsuya , Kazuhiko Iikubo , Yutaka Kondoh , Akio Kamikawa , Hiroshi Tomiyama , Yoshinori Iwai
- Applicant: Itsuro Shimada , Kazuo Kurosawa , Takahiro Matsuya , Kazuhiko Iikubo , Yutaka Kondoh , Akio Kamikawa , Hiroshi Tomiyama , Yoshinori Iwai
- Applicant Address: JP Tokyo JP Hanishina-gun
- Assignee: Astellas Pharma Inc.,Kotobuki Pharmaceutical Co., Ltd.
- Current Assignee: Astellas Pharma Inc.,Kotobuki Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo JP Hanishina-gun
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2009-113936 20090508
- International Application: PCT/JP2010/057751 WO 20100506
- International Announcement: WO2010/128659 WO 20101111
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/497 ; A61K31/4965 ; A61K31/505 ; A61K31/54 ; C07D243/08 ; C07D413/14 ; C07D241/02 ; C07D237/02 ; C07D401/12 ; C07D239/48 ; C07D241/26 ; C07D241/28 ; C07D401/14 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D471/08 ; C07D491/113
Abstract:
Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein.As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.
Public/Granted literature
- US20120040968A1 DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND Public/Granted day:2012-02-16
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