Invention Grant
- Patent Title: Crystalline form of an inhibitor of MDM2/4 and p53 interaction
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Application No.: US13298351Application Date: 2011-11-17
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Publication No.: US08969351B2Publication Date: 2015-03-03
- Inventor: Joerg Berghausen , Haixia Ren
- Applicant: Joerg Berghausen , Haixia Ren
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Michelle Han; Matthew E. Mulkeen
- Priority: WOPCT/CN2010/078927 20101119
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D241/10 ; C07D401/12
Abstract:
A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively.
Public/Granted literature
- US20120129871A1 Crystalline form of an inhibitor of MDM2/4 and p53 interaction Public/Granted day:2012-05-24
Information query
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