Invention Grant
US08969364B2 Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
有权
儿茶酚O-甲基转移酶的抑制剂及其在治疗精神病中的应用
- Patent Title: Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
- Patent Title (中): 儿茶酚O-甲基转移酶的抑制剂及其在治疗精神病中的应用
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Application No.: US13582637Application Date: 2011-02-28
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Publication No.: US08969364B2Publication Date: 2015-03-03
- Inventor: Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
- Applicant: Scott Wolkenberg , Scott T. Harrison , James C. Barrow , Zhijian Zhao , Jeffrey Melamed , Nathan R. Kett , Amy Zartman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agency: Fox Rothschild LLP
- Agent Gerard P. Norton; Jin Zhu
- International Application: PCT/US2011/026424 WO 20110228
- International Announcement: WO2011/109267 WO 20110909
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D401/14 ; A61K31/519 ; C07D239/54 ; C07D239/553 ; C07D401/04 ; C07D401/10 ; C07D403/10 ; C07D405/10 ; C07D409/10 ; C07D413/10 ; C07D417/10 ; C07D471/04 ; C07D498/04 ; A61K31/513 ; A61K45/06
Abstract:
The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
Public/Granted literature
- US20130196002A1 INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS Public/Granted day:2013-08-01
Information query
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