Invention Grant
US08969389B2 Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators
有权
取代的6-甲基烟酰胺作为mGluR5阳性变构调节剂
- Patent Title: Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators
- Patent Title (中): 取代的6-甲基烟酰胺作为mGluR5阳性变构调节剂
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Application No.: US13114958Application Date: 2011-05-24
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Publication No.: US08969389B2Publication Date: 2015-03-03
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Ya Zhou , Jason Manka , Gregor McDonald , José Manuel Bartolome-Nebreda
- Applicant: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Ya Zhou , Jason Manka , Gregor McDonald , José Manuel Bartolome-Nebreda
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: A61K31/44
- IPC: A61K31/44
Abstract:
In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20110294858A1 SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2011-12-01
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