Invention Grant
- Patent Title: Thiophenecarboxamide derivatives as EP4 receptor ligands
- Patent Title (中): 噻吩甲酰胺衍生物作为EP4受体配体
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Application No.: US12309941Application Date: 2007-08-10
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Publication No.: US08969394B2Publication Date: 2015-03-03
- Inventor: Marc Blouin , Jason Burch , Yongxin Han , Christophe Mellon
- Applicant: Marc Blouin , Jason Burch , Yongxin Han , Christophe Mellon
- Applicant Address: CA Kirkland, Quebec
- Assignee: Merck Frosst Canada Ltd.
- Current Assignee: Merck Frosst Canada Ltd.
- Current Assignee Address: CA Kirkland, Quebec
- Agent Matthew A. Leff; John C. Todaro
- International Application: PCT/CA2007/001404 WO 20070810
- International Announcement: WO2008/017164 WO 20080214
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/381 ; A61P29/00 ; C07D333/38 ; C07D409/12
Abstract:
The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II).
Public/Granted literature
- US20090247596A1 THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS Public/Granted day:2009-10-01
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