Invention Grant
- Patent Title: Triterpenoid derivatives useful as antiproliferative agents
- Patent Title (中): 三萜衍生物可用作抗增殖剂
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Application No.: US13321269Application Date: 2010-05-20
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Publication No.: US08969395B2Publication Date: 2015-03-03
- Inventor: Jorge Antonio Ribeiro Salvador , Rita Catarina Mendes Dos Santos , Marta Cascante Serratosa
- Applicant: Jorge Antonio Ribeiro Salvador , Rita Catarina Mendes Dos Santos , Marta Cascante Serratosa
- Applicant Address: PT Coimbra
- Assignee: Universidade de Coimbra
- Current Assignee: Universidade de Coimbra
- Current Assignee Address: PT Coimbra
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Priority: PT104607 20090520
- International Application: PCT/PT2010/000021 WO 20100520
- International Announcement: WO2010/134830 WO 20101125
- Main IPC: A61K31/56
- IPC: A61K31/56 ; C07J53/00 ; A61K31/4166 ; A61K31/4178 ; A61K31/4196 ; C07D233/60 ; C07D249/08 ; C07J63/00
Abstract:
Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth and for treating cancer and other proliferative diseases, more particularly for treating leukemia, liver, cervical, colon and prostate cancer. The present invention also relates to the synthesis of these compounds and to pharmaceutical compositions which contain them.
Public/Granted literature
- US20120129901A1 TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS Public/Granted day:2012-05-24
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