Invention Grant
US08969524B2 FVIII peptides for immune tolerance induction and immunodiagnostics
有权
FVIII肽用于免疫耐受诱导和免疫诊断
- Patent Title: FVIII peptides for immune tolerance induction and immunodiagnostics
- Patent Title (中): FVIII肽用于免疫耐受诱导和免疫诊断
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Application No.: US13283452Application Date: 2011-10-27
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Publication No.: US08969524B2Publication Date: 2015-03-03
- Inventor: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
- Applicant: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
- Applicant Address: US IL Deerfield CH Glattpark (Opfikon)
- Assignee: Baxter International Inc.,Baxter Healthcare SA
- Current Assignee: Baxter International Inc.,Baxter Healthcare SA
- Current Assignee Address: US IL Deerfield CH Glattpark (Opfikon)
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K38/37
- IPC: A61K38/37 ; C07K14/745 ; G01N33/50

Abstract:
The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.
Public/Granted literature
- US20120135019A1 FVIII PEPTIDES FOR IMMUNE TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS Public/Granted day:2012-05-31
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