Invention Grant
- Patent Title: Combined use of PRAME inhibitors and HDAC inhibitors
- Patent Title (中): 组合使用PRAME抑制剂和HDAC抑制剂
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Application No.: US13045284Application Date: 2011-03-10
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Publication No.: US08969544B2Publication Date: 2015-03-03
- Inventor: René Bernards , Mirjam Epping , Liming Wang
- Applicant: René Bernards , Mirjam Epping , Liming Wang
- Agency: Nixon & Vanderhye P.C.
- Priority: GB0401876.8 20040128
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K31/7088 ; A61K31/16 ; A61K31/203 ; A61K45/06 ; C12N15/113 ; A61K31/18 ; A61K48/00
Abstract:
The invention relates to the cancer antigen PRAME (PReferentially expressed Antigen in MElanoma) and its use in a method of treatment of a tumour which comprises administering to a subject in need of treatment an effective amount of an inhibitor of PRAME, in combination with a second agent selected from the group of an inhibitor of HDAC (an HDACi) and a retinoid.
Public/Granted literature
- US20130123327A1 COMBINED USE OF PRAME INHIBITORS AND HDAC INHIBITORS Public/Granted day:2013-05-16
Information query
