Invention Grant
US08969552B2 Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
有权
芳基磺酰基甲基或芳基磺酰胺取代的芳族化合物,适用于治疗对多巴胺D3受体调节作用的疾病
- Patent Title: Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
- Patent Title (中): 芳基磺酰基甲基或芳基磺酰胺取代的芳族化合物,适用于治疗对多巴胺D3受体调节作用的疾病
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Application No.: US11665428Application Date: 2005-10-14
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Publication No.: US08969552B2Publication Date: 2015-03-03
- Inventor: Karla Drescher , Andreas Haupt , Liliane Unger , Sean C. Turner , Wilfried Braje , Roland Grandel , Christophe Henry
- Applicant: Karla Drescher , Andreas Haupt , Liliane Unger , Sean C. Turner , Wilfried Braje , Roland Grandel , Christophe Henry
- Applicant Address: DE Wiesbaden
- Assignee: AbbVie Deutschland GmbH & Co. KG
- Current Assignee: AbbVie Deutschland GmbH & Co. KG
- Current Assignee Address: DE Wiesbaden
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- International Application: PCT/EP2005/011091 WO 20051014
- International Announcement: WO2006/040178 WO 20060420
- Main IPC: C07C311/44
- IPC: C07C311/44 ; C07D207/10 ; C07D211/10 ; C07D215/38 ; C07D263/32 ; C07D413/04 ; C07C311/21 ; C07C311/29 ; C07D239/84 ; C07D277/82 ; C07D311/04 ; C07D491/04

Abstract:
The present invention relates to aromatic compounds of the formula I wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb; X is N or CH; Y is O, S, —CH═N—, —CH═CH— or —N═CH—; A is CH2, O or S; E is CR6R7 or NR3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H, C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, or R1a and R2 together are (CH2)n with n being 2 or 3, or R1a and R2a together are (CH2)n with n being 2 or 3; R2 and R2a are independently of each other H, CH3, CH2F, CHF2 or CF3; R3 is H or C1-C4-alkyl; R6, R7 independently of each other are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
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