Invention Grant
- Patent Title: Inhibitors of STAT3
- Patent Title (中): STAT3抑制剂
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Application No.: US13119575Application Date: 2009-09-17
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Publication No.: US08969578B2Publication Date: 2015-03-03
- Inventor: James Turkson , Andrew D. Hamilton
- Applicant: James Turkson , Andrew D. Hamilton
- Applicant Address: US FL Orlando
- Assignee: University of Central Florida Research Foundation, Inc.
- Current Assignee: University of Central Florida Research Foundation, Inc.
- Current Assignee Address: US FL Orlando
- Agency: Ballard Spahr LLP
- International Application: PCT/US2009/057291 WO 20090917
- International Announcement: WO2010/033685 WO 20100325
- Main IPC: C07D263/00
- IPC: C07D263/00 ; C07D277/00 ; A61K31/41 ; A61K31/421 ; A61K31/426 ; C07D263/34 ; C07D277/56 ; C07F9/12 ; C07F9/653 ; C07F9/6539 ; C07D291/00 ; C12N5/00 ; A61K31/381
Abstract:
Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.
Public/Granted literature
- US20110223661A1 INHIBITORS OF STAT3 Public/Granted day:2011-09-15
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