Invention Grant
- Patent Title: Method for the preparation of cinacalcet and intermediates and impurities thereof
- Patent Title (中): 西那卡塞及其中间体及其杂质的制备方法
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Application No.: US14052116Application Date: 2013-10-11
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Publication No.: US08969623B2Publication Date: 2015-03-03
- Inventor: Vijayavitthal Thippannachar Mathad , Navnath Chintaman Niphade , Gorakshanath Balasaheb Shinde , Sharad Subhash Ippar , Shrikant Prataprao Deshmukh , Raghavendra Kumar Panchangam
- Applicant: Amneal Pharmaceuticals, LLC , Megafine Pharma (P) Ltd.
- Applicant Address: US NJ Bridgewater
- Assignee: Amneal Pharmaceuticals, LLC
- Current Assignee: Amneal Pharmaceuticals, LLC
- Current Assignee Address: US NJ Bridgewater
- Agency: Servilla Whitney LLC
- Priority: IN516/MUM/2009 20090309
- Main IPC: C07C209/00
- IPC: C07C209/00 ; C07C209/62 ; C07C209/86 ; C07C211/08 ; C07C249/02 ; C07C251/30 ; C07C211/30 ; C07C251/16 ; C07C251/24 ; C07C251/06
Abstract:
A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.
Public/Granted literature
- US20140081048A1 Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof Public/Granted day:2014-03-20
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