Embodiments of auto-cladded optical fibers are described. The fibers may have a refractive index profile having a small relative refractive index change. For example, the fiber may include an auto-cladded structure having, e.g., a trough or gradient in the refractive index profile. A beam of light propagating in the fiber may be guided, at least in part, with the auto-cladded structure. In some embodiments, the optical fiber may be all glass. In some embodiments, the optical fiber may include a large-core or an ultra large-core.