Systems and methods for providing a full fail-safe capability in signal transmission networks are disclosed. For example, a system for providing a full fail-safe capability in signal transmission networks includes at least a first electronic circuit to transmit and receive signals or data, at least one driver unit coupled to the at least a first electronic circuit, and at least one receiver unit coupled to the at least a first electronic circuit and the at least one driver unit. The at least one receiver unit includes at least one offset signal generating unit, a signal comparing unit, and a switching unit to couple an offset signal from the at least one offset signal generating unit to an input of the signal comparing unit.