The present subject matter discloses a system and a method for compression of genomic data. In one embodiment, the method for compression of genomic data includes obtaining modified genomic data from genomic data based at least in part on intermediary data identified from the genomic data. In one implementation, the modified genomic data includes a plurality of primary characters. The genomic data may then be modified to generate one or more most-frequent character files based at least on a most-frequent character and a second most-frequent character from among the plurality of primary characters. Further, based at least on the one or more most-frequent character files and the modified genomic data, a least-frequent characters file may be created from the modified genomic data.