A method of prioritizing data transmissions between a SCSI initiator and a SCSI target in a network system with DCB enabled switches. The method includes a switch controller detecting a SCSI set priority response transmitted via a first pair of switch ports from a SCSI target to a SCSI initiator, which communicate SCSI messaging and transmit I/O data via the first pair of switch ports. In response to detecting the SCSI set priority response, the priority data established by the SCSI target is retrieved and, based on the retrieved priority data, the switch controller autonomously sets the DCB priority for the first pair of switch ports to a first DCB priority value correlated to the retrieved priority data. Transmission of the I/O data between the SCSI initiator and the SCSI target is supported with a priority of the first pair of switch ports set to the first DCB priority value.