An engine is disclosed. The engine may have an engine block with a front end, a back end opposite the front end in a length direction, a first side, a second side opposite the first side, a top, and a bottom opposite the top. The engine may also have at least one cylinder head connected to the top of the engine block, and a first heat exchanger mounted at the first side of the engine block and configured to receive a flow of raw coolant and a flow of fresh coolant. The engine may further have a second heat exchanger mounted at the first side of the engine block, between the first heat exchanger and the top. The second heat exchanger may be configured to receive a flow of fresh coolant from the first heat exchanger and a flow of combustion air.