Medical systems, devices and methods are provided for accessing a bodily opening that, among other things, are safe and reliable, and facilitate manipulation of a medical instrument. The medical access device generally includes an elongated flexible sheath and a port connected to the distal end of the flexible sheath. The sheath defines a sheath lumen and a longitudinal axis. The port has an interior surface defining a passageway and an exterior surface that is tapered in a distal direction. The passageway is in communication with the sheath lumen. The exterior surface of the port defines a radially opening channel sized to receive at least a portion of the tissue therein.