Invention Grant
US08974768B2 Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates
有权
偶氮化合物减少淀粉样β聚集中间体的形成和毒性
- Patent Title: Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates
- Patent Title (中): 偶氮化合物减少淀粉样β聚集中间体的形成和毒性
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Application No.: US13636831Application Date: 2011-03-23
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Publication No.: US08974768B2Publication Date: 2015-03-10
- Inventor: Erich Wanker , Thomas Wiglenda , Julius Tachu Babila , Annett Boeddrich , Michael Schmidt , Franziska Schiele
- Applicant: Erich Wanker , Thomas Wiglenda , Julius Tachu Babila , Annett Boeddrich , Michael Schmidt , Franziska Schiele
- Applicant Address: DE Berlin
- Assignee: Max-Delbrueck-Centrum fuer Molekulare Medizin
- Current Assignee: Max-Delbrueck-Centrum fuer Molekulare Medizin
- Current Assignee Address: DE Berlin
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Priority: EP10157378 20100323
- International Application: PCT/EP2011/054462 WO 20110323
- International Announcement: WO2011/117305 WO 20110929
- Main IPC: A61K31/655
- IPC: A61K31/655 ; A61K49/10 ; C07C245/06 ; C07C245/18 ; C07C245/20 ; C07C245/08 ; C07C245/10 ; C07C309/46 ; C07C309/49 ; C07C309/50 ; C07C331/28 ; C07D213/76 ; C07D249/14 ; C07D277/50 ; C07C245/24
Abstract:
The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.
Public/Granted literature
- US20130078186A1 AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES Public/Granted day:2013-03-28
Information query
