Invention Grant
US08974777B2 Adenovirus with mutations in the endoplasmic reticulum retention domain of the E3-19K protein and their use in cancer treatment
有权
E3-19K蛋白质内质网保留结构域突变的腺病毒及其在癌症治疗中的应用
- Patent Title: Adenovirus with mutations in the endoplasmic reticulum retention domain of the E3-19K protein and their use in cancer treatment
- Patent Title (中): E3-19K蛋白质内质网保留结构域突变的腺病毒及其在癌症治疗中的应用
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Application No.: US12557031Application Date: 2009-09-10
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Publication No.: US08974777B2Publication Date: 2015-03-10
- Inventor: Manel Maria Cascallo Piqueras , Alena Gros , Ramon Alemany Bonastre
- Applicant: Manel Maria Cascallo Piqueras , Alena Gros , Ramon Alemany Bonastre
- Applicant Address: ES
- Assignee: Institut CataláD'oncologia
- Current Assignee: Institut CataláD'oncologia
- Current Assignee Address: ES
- Agency: Banner & Witcoff, Ltd.
- Priority: ES200700665 20070314
- Main IPC: C12N7/01
- IPC: C12N7/01 ; A61K48/00 ; C12N15/861 ; A61P35/00
Abstract:
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.
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