Invention Grant
US08975029B2 Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation
有权
整合素α-2结合剂及其用途来抑制癌细胞增殖
- Patent Title: Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation
- Patent Title (中): 整合素α-2结合剂及其用途来抑制癌细胞增殖
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Application No.: US13474872Application Date: 2012-05-18
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Publication No.: US08975029B2Publication Date: 2015-03-10
- Inventor: Stephen J. Weiss , David T. Dudley
- Applicant: Stephen J. Weiss , David T. Dudley
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K16/00 ; C07K16/46 ; C07K16/28 ; A61K39/00
Abstract:
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.
Public/Granted literature
- US20120294865A1 Integrin Alpha-2 Binding Agents and Use Thereof to Inhibit Cancer Cell Proliferation Public/Granted day:2012-11-22
Information query
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