Invention Grant
US08975032B2 Test kit for plasma or serum antibody titer against periodontal disease-causing bacteria 有权
血浆或血清抗体滴定对牙周病致病细菌的试剂盒

  • Patent Title: Test kit for plasma or serum antibody titer against periodontal disease-causing bacteria
  • Patent Title (中): 血浆或血清抗体滴定对牙周病致病细菌的试剂盒
  • Application No.: US13994005
    Application Date: 2011-10-18
  • Publication No.: US08975032B2
    Publication Date: 2015-03-10
  • Inventor: Mikio Nozoe
  • Applicant: Mikio Nozoe
  • Applicant Address: JP Osaka
  • Assignee: Sunstar Inc.
  • Current Assignee: Sunstar Inc.
  • Current Assignee Address: JP Osaka
  • Agency: Wenderoth, Lind & Ponack, L.L.P.
  • Priority: JP2010-279268 20101215
  • International Application: PCT/JP2011/073942 WO 20111018
  • International Announcement: WO2012/081306 WO 20120621
  • Main IPC: G01N33/68
  • IPC: G01N33/68 G01N33/569 C07K14/195 G01N33/543
Test kit for plasma or serum antibody titer against periodontal disease-causing bacteria
Abstract:
The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be treated by an automated device at a high speed; a periodontal disease-causing bacterium antigen protein which can be suitably used in the kit; a method for testing an antibody titer or the presence of an antibody in a blood sample using the kit; and a kit for typing strains of Porphyromonas gingivalis. The present invention discloses: a test kit comprising a set of polypeptides respectively having the acid sequences represented by SEQ ID NOs: 1, 3, 9, 15, 19, 31, 41, 43, 63, 65 and 67; a modified polypeptide having the amino acid sequence represented by SEQ ID NO: 67; and a method for determining an antibody titer or the presence of an antibody against a periodontal disease-causing bacterium in a blood sample separated from a human body, comprising bringing the blood sample into contact with the above-mentioned set of polypeptides.
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