Invention Grant
- Patent Title: Isolated stem cell comprising a Xic flanking region transgene
- Patent Title (中): 分离的干细胞，其包含Xic侧翼区转基因
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Application No.: US12523018Application Date: 2008-01-24
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Publication No.: US08975068B2Publication Date: 2015-03-10
- Inventor: Jeannie T. Lee
- Applicant: Jeannie T. Lee
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Clark & Elbing LLP
- International Application: PCT/US2008/000959 WO 20080124
- International Announcement: WO2008/091680 WO 20080731
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/0735 ; C12N15/90 ; C12N15/86 ; C12N15/113 ; C12N15/63 ; C12N5/16 ; C12N15/85 ; C12N15/11
Abstract:
Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having Xic, Tsix, Xite, or Xic flanking region sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small RNA molecules and methods for using the small RNA molecules to control stem cell differentiation. Also disclosed are stem cells genetically modified by the introduction of Xic, Tsix, XUe, or Xic flanking region sequences.
Public/Granted literature
- US20100203632A1 METHODS FOR CONTROLLING STEM CELL DIFFERENTIATION Public/Granted day:2010-08-12
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