Invention Grant
- Patent Title: Macrocyclic kinase inhibitors and uses thereof
- Patent Title (中): 大环激酶抑制剂及其用途
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Application No.: US13812431Application Date: 2011-07-29
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Publication No.: US08975232B2Publication Date: 2015-03-10
- Inventor: David R. Liu , Ralph E. Kleiner
- Applicant: David R. Liu , Ralph E. Kleiner
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent C. Hunter Baker; Robin A. Weatherhead
- International Application: PCT/US2011/045966 WO 20110729
- International Announcement: WO2012/016186 WO 20120202
- Main IPC: A61P35/00
- IPC: A61P35/00 ; C07K5/02 ; A61K38/12 ; C07K5/107
Abstract:
The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI, f, g, h, n, and m are as defined herein. The present invention further provides methods of synthesizing these macrocyclic compounds, and methods of their use and treatment. Certain aspects of the present invention relate to modulation of kinase activity, and in the treatment of kinase-associated diseases or disorders.
Public/Granted literature
- US20130178429A1 MACROCYCLIC KINASE INHIBITORS AND USES THEREOF Public/Granted day:2013-07-11
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
