Invention Grant
US08975257B2 Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
有权
制备3-O-保护的吗啡酮和3-O-保护的吗啡酮二烯酚羧酸酯的方法
- Patent Title: Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
- Patent Title (中): 制备3-O-保护的吗啡酮和3-O-保护的吗啡酮二烯酚羧酸酯的方法
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Application No.: US14188430Application Date: 2014-02-24
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Publication No.: US08975257B2Publication Date: 2015-03-10
- Inventor: Andreas Stumpf
- Applicant: Purdue Pharma L.P.
- Applicant Address: US CT Stamford
- Assignee: Purdue Pharma L.P.
- Current Assignee: Purdue Pharma L.P.
- Current Assignee Address: US CT Stamford
- Agency: Dechert LLP
- Main IPC: A61K31/53
- IPC: A61K31/53 ; A61K31/485 ; C09K3/00 ; C07F7/18 ; C07D489/02 ; C07D491/22
Abstract:
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.
Public/Granted literature
- US20140171643A1 METHODS FOR MAKING 3-O-PROTECTED MORPHINONES AND 3-O-PROTECTED MORPHINONE DIENOL CARBOXYLATES Public/Granted day:2014-06-19
Information query
