Invention Grant
- Patent Title: Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors
- Patent Title (中): 丙烯酰氧基甲基环丙烷衍生物作为PDE10抑制剂
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Application No.: US14117313Application Date: 2012-05-21
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Publication No.: US08975261B2Publication Date: 2015-03-10
- Inventor: Michael J. Breslin , Christopher D. Cox , Timothy J. Hartingh , Joseph Pero , Izzat T. Raheem , Michael Rossi , Laura Vassallo
- Applicant: Michael J. Breslin , Christopher D. Cox , Timothy J. Hartingh , Joseph Pero , Izzat T. Raheem , Michael Rossi , Laura Vassallo
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- International Application: PCT/US2012/038759 WO 20120521
- International Announcement: WO2012/162213 WO 20121129
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D239/34 ; A61K31/444 ; C07D487/04 ; C07D413/14 ; C07D401/12 ; C07D403/14 ; C07D417/14 ; C07D471/04
Abstract:
The present invention is directed to aryloxymethyl cyclopropane derivatives which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
Public/Granted literature
- US20140336195A1 ARYLOXMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS Public/Granted day:2014-11-13
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