Invention Grant
US08975284B2 Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents
有权
辅助溶剂组合物和用于改善丹特罗林治疗剂递送的方法
- Patent Title: Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents
- Patent Title (中): 辅助溶剂组合物和用于改善丹特罗林治疗剂递送的方法
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Application No.: US12205303Application Date: 2008-09-05
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Publication No.: US08975284B2Publication Date: 2015-03-10
- Inventor: Ahmad Malkawi , Abeer M. Al-Ghananeem , Patrick DeLuca , George A. Digenis
- Applicant: Ahmad Malkawi , Abeer M. Al-Ghananeem , Patrick DeLuca , George A. Digenis
- Applicant Address: US KY Louisville
- Assignee: US WorldMeds LLC
- Current Assignee: US WorldMeds LLC
- Current Assignee Address: US KY Louisville
- Agency: Frost Brown Todd LLC
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A61K31/44 ; A01N43/50 ; A61K31/415 ; A01N43/00 ; A61K31/33 ; A61K9/00 ; A61K9/08 ; A61K9/19 ; A61K31/4166 ; A61K31/4168
Abstract:
The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
Public/Granted literature
- US20110160261A2 CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS Public/Granted day:2011-06-30
Information query
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