Invention Grant
- Patent Title: Ether benzotriazole derivatives
- Patent Title (中): 醚苯并三唑衍生物
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Application No.: US13391315Application Date: 2010-08-16
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Publication No.: US08975286B2Publication Date: 2015-03-10
- Inventor: Vadim Y. Dudkin , Mark E. Fraley , Cheng Wang , Robert M. Garbaccio , Douglas C. Beshore , Scott K. Kuduk , Jason W. Skudlarek
- Applicant: Vadim Y. Dudkin , Mark E. Fraley , Cheng Wang , Robert M. Garbaccio , Douglas C. Beshore , Scott K. Kuduk , Jason W. Skudlarek
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; John C. Todaro
- International Application: PCT/US2010/045566 WO 20100816
- International Announcement: WO2011/022312 WO 20110224
- Main IPC: C07D409/14
- IPC: C07D409/14 ; C07D405/14 ; C07D401/14 ; C07D401/12 ; C07D403/12 ; C07D249/18 ; A61K31/506 ; A61K31/497 ; A61K31/496 ; A61K31/454 ; A61K31/4545 ; A61K31/444 ; A61K31/4439 ; A61K31/4192 ; C07D417/14 ; C07D403/14 ; C07D413/14 ; C07D417/12 ; C07D471/04 ; C07D471/08 ; C07D471/10 ; C07D487/04 ; C07D487/08 ; C07D487/10 ; C07D495/04
Abstract:
The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
Public/Granted literature
- US20120149677A1 ETHER BENZOTRIAZOLE DERIVATIVES Public/Granted day:2012-06-14
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