Invention Grant
US08975290B2 Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis
有权
用于增强免疫应答，阻断单核细胞迁移，扩大疫苗免疫和抑制肿瘤生长和转移的方法和组合物
- Patent Title: Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis
- Patent Title (中): 用于增强免疫应答，阻断单核细胞迁移，扩大疫苗免疫和抑制肿瘤生长和转移的方法和组合物
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Application No.: US14195688Application Date: 2014-03-03
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Publication No.: US08975290B2Publication Date: 2015-03-10
- Inventor: Steven W. Dow , Daniel P. Regan , Amanda M. Guth , Leah Mitchell
- Applicant: Colorado State University Research Foundation
- Applicant Address: US CO Fort Collins
- Assignee: Colorado State University Research Foundation
- Current Assignee: Colorado State University Research Foundation
- Current Assignee Address: US CO Fort Collins
- Agency: Cooley LLP
- Main IPC: A61K31/415
- IPC: A61K31/415
Abstract:
Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided.
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