Invention Grant
US08975293B2 Epigenetic co-repressors of the gamma-globin gene and methods of using same
有权
γ-珠蛋白基因的表观遗传学共抑制因子及其使用方法
- Patent Title: Epigenetic co-repressors of the gamma-globin gene and methods of using same
- Patent Title (中): γ-珠蛋白基因的表观遗传学共抑制因子及其使用方法
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Application No.: US13480036Application Date: 2012-05-24
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Publication No.: US08975293B2Publication Date: 2015-03-10
- Inventor: James Douglas Engel , Osamu Tanabe , Lihong Shi
- Applicant: James Douglas Engel , Osamu Tanabe , Lihong Shi
- Applicant Address: US MI Ann Arbor
- Assignee: Regents of the University of Michigan
- Current Assignee: Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Fish & Richardson P.C.
- Main IPC: A61P7/00
- IPC: A61P7/00 ; A61K31/708 ; G01N33/68 ; G01N33/80
Abstract:
This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
Public/Granted literature
- US08916608B2 Epigenetic co-repressors of the gamma-globin gene and methods of using same Public/Granted day:2014-12-23
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