Invention Grant
- Patent Title: Nucleic acid chemical modifications
- Patent Title (中): 核酸化学修饰
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Application No.: US13203927Application Date: 2010-03-02
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Publication No.: US08975389B2Publication Date: 2015-03-10
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , Alexander V. Kelin , Sudhakar Rao Takkellapati , Shigeo Matsuda
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , Alexander V. Kelin , Sudhakar Rao Takkellapati , Shigeo Matsuda
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- International Application: PCT/US2010/025966 WO 20100302
- International Announcement: WO2010/101951 WO 20100910
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C07H19/04 ; C07H19/10 ; C07H19/073 ; C07H19/173 ; C07H19/20
Abstract:
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Public/Granted literature
- US20120071641A1 NUCLEIC ACID CHEMICAL MODIFICATIONS Public/Granted day:2012-03-22
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