Invention Grant
US08975400B2 2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors
有权
2,3-二氢咪唑并[1,2-c]嘧啶-5（1H） - 酮化合物用作LP-PLA2抑制剂
![2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors](/docs/US/2015-03-10/US08975400B2/abs.jpg.600x600.jpg)
- Patent Title: 2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors
- Patent Title (中): 2,3-二氢咪唑并[1,2-c]嘧啶-5（1H） - 酮化合物用作LP-PLA2抑制剂
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Application No.: US14234680Application Date: 2012-07-25
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Publication No.: US08975400B2Publication Date: 2015-03-10
- Inventor: Zehong Wan , Kai Long , Yingxia Sang , Xiaobo Su
- Applicant: Zehong Wan , Kai Long , Yingxia Sang , Xiaobo Su
- Applicant Address: GB Brentford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Fang Qian; William R. Majarian; Carl Battle
- Priority: CNPCT/CN2011/077697 20110727
- International Application: PCT/CN2012/000999 WO 20120725
- International Announcement: WO2013/013503 WO 20130131
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P25/28 ; C07D401/12 ; A61K31/4427
![2,3-dihydroimidazo[1, 2-c] pyrimidin-5(1 H)-one compounds use as LP-PLA2 inhibitors](/abs-image/US/2015/03/10/US08975400B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are 2,3-dihydroimiazo[1,2-c]pyrimidin-5(IH)-one compounds that inhibit Lp-PLA2,processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
Public/Granted literature
- US20140179715A1 2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS Public/Granted day:2014-06-26
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