Invention Grant
- Patent Title: Arylsulfonamide based matrix metalloprotease inhibitors
- Patent Title (中): 基于芳基磺酰胺的基质金属蛋白酶抑制剂
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Application No.: US13690274Application Date: 2012-11-30
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Publication No.: US08975439B2Publication Date: 2015-03-10
- Inventor: Ruben Alberto Tommasi , Michael David Shultz , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Claus Ehrhardt
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Sophie Binet-Cross
- Main IPC: C07C311/16
- IPC: C07C311/16 ; A61K31/18 ; C07D207/333 ; C07D209/12 ; C07C317/24 ; C07D295/112 ; A61K45/06 ; C07D403/04 ; C07D409/04 ; A61K31/55 ; C07D209/82 ; C07D235/06 ; C07D241/04 ; C07C323/67 ; C07D211/14 ; C07D265/30 ; C07D211/06 ; C07D213/61 ; C07D213/50 ; C07D471/04 ; C07D209/14 ; C07D211/24 ; C07D209/08 ; C07D209/10 ; C07D333/22 ; A61K31/4402 ; C07D401/04 ; C07D295/116 ; C07C311/46 ; C07D223/04 ; C07D333/18 ; C07D413/04 ; C07D221/16 ; C07D295/192 ; C07D207/20 ; A61K31/451 ; C07D209/80 ; A61K31/437 ; C07D213/40 ; C07C311/29 ; C07D487/04 ; C07D231/56 ; A61K31/495 ; C07C311/39 ; C07D235/08 ; A61K31/5375
Abstract:
The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
Public/Granted literature
- US20130096105A1 ArylSulfonamide Based Matrix Metalloprotease Inhibitors Public/Granted day:2013-04-18
Information query
