Systems, methods, and other embodiments associated with producing spatially varying spectral response calibration data are described. One example method includes controlling a digital camera to capture characteristic data arrays from light sensors in the digital camera in response to the digital camera being exposed to light stimuli from a multi-spectral reference display. The data arrays will be acquired multiple times at multiple locations in multiple stimuli provided from the multi-spectral reference display. The method also includes controlling a calibration logic to manipulate characteristic data arrays to produce spatially varying spectral response calibration data as a function of using characteristic data arrays and known wavelengths of the light in light stimuli. The method may also include providing the spatially varying spectral response calibration data to a downstream consumer (e.g., correction process, quality control process), displaying the data, or storing the data.