Systems and methods of interference-triggered frequency hopping in a wireless communication system. A master is provided in the wireless communication system in wireless communication with slave nodes each configured to use different preselected communication frequencies to permit frequency hopping. A current channel is selected from among multiple channels in the wireless communication system in which the master and at least some of the slave nodes send and receive wireless communications. Each of the channels uses different ones of the preselected communication frequencies. In the current channel, interference with communications between the master and a selected one of the slave nodes that use the current channel is detected. A new channel is selected only in response to detecting the interference. The system switches from the current channel to the new channel such that communications between the master and the selected slave node use the new channel.